The world has been very careful to pick very few diseases for eradication, because it is very tough.
Break-ups are hard for anybody, but it's particularly tough when it's being documented and you see the person's picture everywhere. Most people don't have that added problem when they break up with someone.
After you manage the Yankees for 12 years, it's really tough to envision going somewhere else. But then the Dodgers called.
Your job as a parent is to listen. And to dole out as much love as you can. That includes tough love.
Paul Volcker is a tremendous hero with the Federal Reserve system and for the American economy. He took very tough actions and helped to break the back of double-digit inflation at a time when it had to be done.
Being tough on China is one thing. Being completely erratic with no strategy and dragging businesses and farmers through the mud, using them as pawns in the game, is not the way to beat China.
Planned Parenthood is a tough place to work - the hours are long, the work is emotionally draining, the paperwork is endless, and the morale can run low.
It's tough to stay married. My wife kisses the dog on the lips, yet she won't drink from my glass.
When I first started shooting 'Sharpe,' back in the early 1990s, I'd kiss my two elder daughters goodbye at the end of August - Evie wasn't even born then - and I wouldn't see them again until Christmas. That was tough. They were hard times.
One of the tough things about being an actor, probably the hardest thing, is getting your foot in the door, and my father handled that for me at a very early age.
I'm too tough and sensitive to have to have some pubescent twerp with his mom's earring in his tongue, who combs his hair with Redi-Whip and has an Ani DiFranco tattoo on his shin, come show me how a computer works.
When you are tough on yourself, life is going to be infinitely easier on you.
Great opportunities can be and have been created during tough economic times.
Nothing takes the sting out of these tough economic times like watching a bunch of millionaires giving golden statues to each other.
The pitch that works best in tough economic times is, 'I can do that for less.'
We are going through tough economic times but things are looking up, and the indicators are improving not only for large corporations but also for small business.
During these continued tough economic times, writing a sensible, fair budget that provides real opportunities for Washington families, workers and businesses is always a challenge.
'Edward Scissorhands' was tough to let go of because I found real safety in allowing myself to be that open, that honest. To explore purity. It was a hard one to walk away from.
I'm quite used to playing with few injuries, whether it is back, fingers, elbow, or something else. You have to be tough and get on with the game.
Diana Wynne Jones' excellent book 'The Tough Guide to Fantasyland' is a compendium of the sort of lazy writing that has given fantasy fiction - especially the sub-section that features elves and dwarves and other Tolkienesque elements - a bad name.