What do you most value in your friends? Their continued existence.
What do you regard as the lowest depth of misery? (Just to give you an idea, Proust's reply was 'To be separated from Mama.') I think that the lowest depth of misery ought to be distinguished from the highest pitch of anguish. In the lower depths come enforced idleness, sexual boredom, and/or impotence. At the highest pitch, the death of a friend or even the fear of the death of a child.