There was a long history of speculation that in quantum gravity, unlike Einstein's classical theory, it might be possible for the topology of spacetime to change.
I just think too many nice things have happened in string theory for it to be all wrong. Humans do not understand it very well, but I just don't believe there is a big cosmic conspiracy that created this incredible thing that has nothing to do with the real world.
So when you ask me how string theory might be tested, I can tell you what's likely to happen at accelerators or some parts of the theory that are likely to be tested.
If you are a researcher, you are trying to figure out what the question is as well as what the answer is.
Quantum mechanics brought an unexpected fuzziness into physics because of quantum uncertainty, the Heisenberg uncertainty principle.
One very important aspect of string theory is definitely testable. That was the prediction of supersymmetry, which emerged from string theory in the early '70s.
