There's a fraudulent root element of comedy in that we say things night after night as though they are rolling effortlessly from the brain and off the tongue, when in fact they are crafted over weeks and months and years.
I think it's probably much easier to do political comedy from a two-party point of view, in that the majority have some sense of what it means to be one or the other.
Comedy can always be taken the wrong way. If I do a bit that is meant to diffuse racism or sexism, I'm not going to avoid it on the chance that a small portion of the audience might take it the wrong way.