It would be great if you could cool the water and immobilise the molecules, though keeping the structure, because when it's frozen, when it's immobilised, you can have it in the electron microscope and the water will not evaporate because in the electron microscope, it must be under vacuum, and water at normal temperature evaporates.
We three have never been very good chemists but we are gratified with a Nobel Prize in Chemistry. The Peter Principle says that everyone is promoted until they reach their level of incompetence. We are worried that we may have reached this remarkable point.
We see chemistry, how the atoms are arranged in the molecules, how the disease changes the arrangement. Perhaps we will find which drug disentangles the aggregates that make a brain senile. Many of us are interested in such things.