What do you regard as the lowest depth of misery? (Just to give you an idea, Proust's reply was 'To be separated from Mama.') I think that the lowest depth of misery ought to be distinguished from the highest pitch of anguish. In the lower depths come enforced idleness, sexual boredom, and/or impotence. At the highest pitch, the death of a friend or even the fear of the death of a child.
In Sarajevo in 1992, while being shown around the starved, bombarded city by the incomparable John Burns, I experienced four near misses in all, three of them in the course of one day. I certainly thought that the Bosnian cause was worth fighting for and worth defending, but I could not take myself seriously enough to imagine that my own demise would have forwarded the cause. (I also discovered that a famous jaunty Churchillism had its limits: the old war-lover wrote in one of his more youthful reminiscences that there is nothing so exhilarating as being shot at without result. In my case, the experience of a whirring, whizzing horror just missing my ear was indeed briefly exciting, but on reflection made me want above all to get to the airport. Catching the plane out with a whole skin is the best part by far.) Or suppose I had been hit by that mortar that burst with an awful shriek so near to me, and turned into a Catherine wheel of body-parts and (even worse) body-ingredients? Once again, I was moved above all not by the thought that my death would 'count,' but that it would not count in the least.
Alcohol makes other people less tedious, and food less bland, and can help provide what the Greeks called entheos, or the slight buzz of inspiration when reading or writing. The only worthwhile miracle in the New Testament—the transmutation of water into wine during the wedding at Cana—is a tribute to the persistence of Hellenism in an otherwise austere Judaea. The same applies to the seder at Passover, which is obviously modeled on the Platonic symposium: questions are asked (especially of the young) while wine is circulated. No better form of sodality has ever been devised: at Oxford one was positively expected to take wine during tutorials. The tongue must be untied. It's not a coincidence that Omar Khayyam, rebuking and ridiculing the stone-faced Iranian mullahs of his time, pointed to the value of the grape as a mockery of their joyless and sterile regime. Visiting today's Iran, I was delighted to find that citizens made a point of defying the clerical ban on booze, keeping it in their homes for visitors even if they didn't particularly take to it themselves, and bootlegging it with great brio and ingenuity. These small revolutions affirm the human.
We keep on being told that religion, whatever its imperfections, at least instills morality. On every side, there is conclusive evidence that the contrary is the case and that faith causes people to be more mean, more selfish, and perhaps above all, more stupid.