Elon Musk is a remarkable individual.
I do think there are more and more entrepreneurs all the time that think big. Those are the people we should be finding and funding. Most of them will fail, but the ones who succeed will change the world, and that is progress.
IT is permeating more industries. Moore's Law knocks down simulation capabilities. We don't need wind tunnels anymore, for example. You can run experiments more quickly.
The bad news is that most traditional VCs have a youth bias that they will state very overtly. You always wonder if that's a self-fulfilling prophecy or if it's something about the nature of those businesses.
Being slick is not the right answer.
Statistical physics or Newtonian physics gives way to quantum physics. Very unusual properties of matter emerge at that scale, and you can think about building products in a very different way. You can think about interfacing to biology in a very different way.