Concepts are vindicated by the constant accrual of data and independent verification of data. No prize, not even a Nobel Prize, can make something true that is not true.
While it is quite reasonable for scientists to be skeptical of new ideas that do not fit within the accepted realm of scientific knowledge, the best science often emerges from situations where results carefully obtained do not fit within the accepted paradigms.
My three years at the NIH were critical in my scientific education. I learned an immense amount about the research process: developing assays, purifying macromolecules, documenting a discovery by many approaches, and writing clear manuscripts describing what is known and what remains to be investigated.
In science, each new result, sometimes quite surprising, heralds a step forward and allows one to discard some hypotheses, even though one or two of these might have been highly favored.